Extracellular In Vitro Recording and Stimulation at the Highest Resolution

4225 low noise recording electrodes with either 16 or 32 µm interelectrode distance, sampled at 25 kHz guarantee precise data down to the sub-cellular level.

The ability to address 1024 discreet sites allows precise stimulation of neuronal networks.

Extracellular In Vitro Recording and Stimulation at the Highest Resolution

4225 low noise recording electrodes with either 16 or 32 µm interelectrode distance, sampled at 25 kHz guarantee precise data down to the sub-cellular level.

The ability to address 1024 discreet sites allows precise stimulation of neuronal networks.

Overview

The CMOS-MEA5000-System consists of four components, which are all designed to be efficient and powerful, while fitting ideally on the lab bench and microscopes.

  • CMOS-MEA
  • Headstage
  • Interface board
  • PC Workstation

Main Features

  • 4225 recording channels at 25 kHz sampling rate
  • 1024 stimulation sites
  • Highest resolution for recordings at sub-cellular level
  • Integrated stimulator ideal for closed-loop experiments
  • Data acquisition, visualization, and analysis software suite
  • Outstanding signal quality
  • USB 3.0 connectivity
  • Optimized for brain slices, neuronal cell cultures, or retina preparations

CMOS-MEA

CMOS-MEAs are optimized to capture the electrical activity of neuronal networks at single cell or sub-cellular resolution as in signal propagation along axons.

CMOS-MEA

CMOS-MEAs are optimized to capture the electrical activity of neuronal networks at single cell or sub-cellular resolution as in signal propagation along axons.

Headstage

Designed to be compatible with most microscope stages and takes up limited space on the lab bench. Amplifies and samples data at 25 kHz and ensures high quality data through 14 bit A/D conversion. Integrated 3-channel stimulator with freely programmable independent stimulation patterns.

Interface Board

Gathers data from the headstage and various external instruments via multiple analog or digital inputs and outputs. High speed data transfer to the PC is ensured with USB 3.0 SuperSpeed connection.

As the heart of the MCS recording platform, the MCS-IFB can also be used with various other MCS headstages for in vitro or in vivo experiments.

PC Workstation

High resolution MEA data acquisition requires powerful computing. The PC Workstation ensures state of the art data processing speed and the software suite (CMOS-MEA-Control and CMOS-MEA-Tools) allow for efficient experimental design and offline data analysis.

Got your Interest?

We are happy to provide any additional information you require.

Tech Specs

Physical Specs

Dimensions (W x D x H)

headstage: 256 mm x 230 mm x 25 mm

interface board: 250 mm x 83 mm x 25 mm

Weight

headstage: approx. 1.4 kg

interface board: approx. 0.3 kg

Body material

anodized aluminum and stainless steel

Amplifier

Data resolution

14 bit

Number of recording channels

4,225

Bandwidth

DC to 10 kHz

Stimulus generator

Number of stimulation patterns

3 independent patterns

Signal shapes

freely programmable

Stimulation sites

1,024

Output voltage

3.4 V amplitude with 10 μs rise time for high capacitive currents

Data converter and USB interface

Control interface

USB 3.0 SuperSpeed

Sampling rate per channel

up to 25 kHz on all channels simultaneously

Temperature control

Heating element impedance

20 Ω

Temperature sensor type

PT 100 with 4 wire connection

Software and PC

Operating system

Data

CMOS-MEA-Control software

Recording and online visualization

CMOS-MEA-Tools software

Offline analysis

Data format

HDF5

PC

High end PC with fast data storage (SSD)